![]() Benign or malignant tumors secrete hormones. Diseases associated with the adrenals include Addison and Cushing.Įctopic secretion refers to the production of a hormone outside of its normal physiology mechanism. The adrenal can also be hypofunctioning or hyperfunctioning. It is a pituitary infarct after massive blood loss during childbirth. Sheehan syndrome is a less common cause of pituitary insufficiency. It can also be caused by pituitary apoplexy, a sudden hemorrhage into a pituitary tumor causing sudden loss of ACTH. Pituitary insufficiency is usually the result of an adenoma that destroys the gland. The pituitary can be hypofunctioning or hyperfunctioning, leading to either a decrease or increase, respectively, in ACTH. Issues can be with the pituitary, adrenals, or ectopic secretion. ![]() Pathophysiology associated with ACTH can stem from 3 different mechanisms.
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